The effect of C1 inhibitor upon Hageman factor autoactivation
نویسندگان
چکیده
منابع مشابه
The effect of C1 inhibitor upon Hageman factor autoactivation.
Using components purified from human plasma, we have examined the effects of C1 inhibitor (C1 INH), the primary inhibitor of activated Hageman Factor (HFa) and Hageman factor fragment (HFf), on Hageman Factor (HF) autoactivation. When Hageman factor was exposed to a negatively charged surface, provided by either a glass cuvette or dextran sulfate, the addition of C1 INH gave a dose-dependent in...
متن کاملThe Effect ofCl Inhibitor Upon Hageman Factor Autoactivation
Using components purified from human plasma. we have examined the effects of Cl Inhibitor (CI INH). the primary inhibitor of activated Hageman Factor (HFa) and Hageman factor fragment (HFf). on Hageman Factor (HF) autoactivation. When Hageman factor was exposed to a negatively charged surface. provided by either a glass cuvette or dextran sulfate, the addition of CI INH gave a dosedependent inh...
متن کاملThe autoactivation of rabbit hageman factor
Proteolytic cleavage and activation of isolated, single chain, zymogen Hageman factor was observed in the presence of kaolin alone. The rate of cleavage of kaolin-bound Hageman factor was enhanced 50-fold by the presence of prekallikrein and high molecular weight kininogen. The two-chain 82,000 dalton form of activated Hageman factor (alpha-HF(a)) also cleaved kaolin- bound single-chain Hageman...
متن کاملThe autoactivation of Factor XII ( Hageman factor ) induced by low - iMr heparin and dextran sulphate
Human Factor XII is known to undergo autoactivation in the presence of dextran sulphate of Mr 500000. We have now studied the dependence of this reaction on the Mr of the dextran sulphate by using fractions resolved by gel filtration. We have found that autoactivation can be induced by dextran sulphate fractions with Mr as-low as 3000, and there is a marked dependence of the rate constant of au...
متن کاملSulfatide-dependent autoactivation of human blood coagulation Factor XII (Hageman Factor).
When purified human blood coagulation Factor XII (Hageman factor) is incubated with sulfatides at 37 degrees C, activation of Factor XII occurs as judged by the appearance of amidolytic activity towards the chromogenic substrate H-D-Pro-Phe-Arg-p-nitroanilide. Polyacrylamide gel electrophoresis studies using 125I-Factor XII as a marker show that the appearance of amidolytic activity correlates ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 1986
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v68.1.239.239